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Read published literature about our products or browse articles about antimicrobial resistance and associated disease states.

Click on a product below to browse recent publications related to Melinta products and associated disease states
 

 

REZZAYO

Registrational and Pivotal Trial Data

Clinical and Mycological Outcomes of Candidaemia and/or Invasive Candidiasis by Candida spp. and Antifungal Susceptibility: Pooled Analyses of Two Randomized Trials of Rezafungin Versus Caspofungin.
Clin Microbiol Infect. 2025 Feb;31(2):250-257. doi: 10.1016/j.cmi.2024.11.029. Epub 2024 Nov 22.

Length of Hospital and Intensive Care Unit Stay in Patients with Invasive Candidiasis and/or Candidemia Treated with Rezafungin: A Pooled Analysis of Two Randomised Controlled Trials.
Crit Care. 2024 Nov 11;28(1):361. doi: 10.1186/s13054-024-05152-2.

Rezafungin Versus Caspofungin for Patients with Candidaemia or Invasive Candidiasis in the Intensive Care Unit: Pooled Analyses of the ReSTORE and STRIVE Randomised Trials.
Crit Care. 2024 Oct 28;28(1):348. doi: 10.1186/s13054-024-05117-5.

Outcomes by Candida spp. in the ReSTORE Phase 3 Trial of Rezafungin Versus Caspofungin for Candidemia and/or Invasive Candidiasis.
Antimicrob Agents Chemother. 2024;68(5):e0158423.

Efficacy and Safety of Rezafungin and Caspofungin in Candidaemia and Invasive Candidiasis: Pooled Data from Two Prospective Randomised Controlled Trials.
Lancet Infect Dis. 2024 Mar;24(3):319-328.

Treatment Outcomes Among Patients With a Positive Candida Culture Close to Randomization Receiving Rezafungin or Caspofungin in the ReSTORE Study.
Clin Infect Dis. 2024;79(3):672-681.

Rezafungin Versus Caspofungin for Treatment Of Candidaemia and Invasive Candidiasis (ReSTORE): A Multicenter, Double-Blind, Double-Dummy, Randomised Phase 3 Trial.
Lancet. 2023;401:49-59.

Rezafungin Versus Caspofungin in A Phase 2, Randomized, Double-Blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial.
Clin Infect Dis. 2021;73(11):e3647-55.

In Vitro Microbiology and Pharmacology Studies

Activity of Rezafungin Against Echinocandin Non–Wild Type Candida glabrata Clinical Isolates from a Global Surveillance Program.
Open Forum Infect Dis. 2025 Mar 3;12(3):ofae702.

Phase I study of the pharmacokinetics and safety of rezafungin in subjects with moderate/severe hepatic impairment and matched control subjects.
Pharmacotherapy. 2024 Jun;44(6):435-443. doi: 10.1002/phar.2943. Epub 2024 Jun 5.

Population Pharmacokinetic Modeling and Target Attainment Analyses of Rezafungin for the Treatment of Candidemia and Invasive Candidiasis.
Antimicrob Agents Chemother. 2023 Dec 14;67(12):e0091623

Absence of Clinically Meaningful Drug-Drug Interactions with Rezafungin: Outcome of Investigations.
Microbiol Spectr. 2023;11(3):e0133923

Population Pharmacokinetics of Rezafungin in Patients with Fungal Infections.
Antimicrob Agents Chemother. 2021;65(11):e0084221

Lack of Effect of Rezafungin on QT/Qtc Interval in Healthy Subjects.
Clin Pharmacol Drug Dev. 2020;9(4):456-465

In Vitro Activity of Rezafungin Against Common and Rare Candida Species and Saccharomyces cerevisiae.
J Antimicrob Chemother. 2019;74(12):3505-3510

Population Pharmacokinetic Analyses for Rezafungin (CD101) Efficacy Using Phase 1 Data.
Antimicrob Agents Chemother. 2018;62(6):e02603-17.

Metabolism, Excretion, and Mass Balance of [14C]-Rezafungin in Animals and Humans.
Antimicrob Agents Chemother. 2018;66(1):e0139021

Safety and Pharmacokinetics of CD101 IV, a Novel Echinocandin, in Healthy Adults.
Antimicrob Agents Chemother. 2017;61(2):e01627-16.

Review Articles

Activity of Rezafungin Against Candida auris.
J Antimicrob Chemother. 2025 Apr 30:dkaf124. doi: 10.1093/jac/dkaf124. Epub ahead of print.

Rezafungin in Special Populations with Candidaemia and/or Invasive Candidiasis.
J Infect. 2025 Feb 5:106435. doi: 10.1016/j.jinf.2025.106435. Epub ahead of print.

Rezafungin: First Approval.
Drugs. 2023;83(9):833-840

VABOMERE

KIMYRSA and ORBACTIV

In Vitro Microbiology and Pharmacology Studies

Population Pharmacokinetic Analysis for a Single 1,200-milligram Dose of Oritavancin using data from Two Pivotal Phase 3 Clinical Trials.
Antimicrob Agents Chemother. 2015;59(6):3365-72

BAXDELA

Registrational and Pivotal Trial Data

A Phase 3 Study to Compare Delafloxacin with Moxifloxacin for the Treatment of Adults with Community-Acquired Bacterial Pneumonia (DEFINE-CABP).
Open Forum Infect Dis. 2019;7(1):ofz514.

Efficacy of Delafloxacin versus Moxifloxacin against Bacterial Respiratory Pathogens in Adults with Community-Acquired Bacterial Pneumonia (CABP): Microbiology Results from the Delafloxacin Phase 3 CABP Trial.
Antimicrob Agents Chemother. 2020;97:374-379.

A Randomized, Double-Blind, Phase 2 Study to Evaluate Subjective and Objective Outcomes in Patients with Acute Bacterial Skin and Skin Structure Infections Treated with Delafloxacin, Linezolid or Vancomycin.
J Antimicrob Chemother. 2016;71(3):821-9.

Analysis of Pooled Phase 3 Safety Data for Delafloxacin in Acute Bacterial Skin and Skin Structure Infections.
Clin Infect Dis. 2019;68(Suppl 3):S233-S240.  

Analysis of Pooled Phase III Efficacy Data for Delafloxacin in Acute Bacterial Skin and Skin Structure Infections.
Clin Infect Dis. 2019;68(Suppl 3):S223-S232.

Efficacy of Delafloxacin Versus Moxifloxacin against Atypical Bacterial Respiratory Pathogens in Adults with Community-Acquired Bacterial Pneumonia (CABP): Data from the Delafloxacin Phase 3 CABP Trial.
Int J Infect Dis. 2020;97:374-379.  

A Comparison of the Efficacy and Safety of Intravenous Followed by Oral Delafloxacin with Vancomycin Plus Aztreonam for the Treatment of Acute Bacterial Skin and Skin Structure Infections: A Phase 3, Multinational, Double-Blind, Randomized Study.
Clin Infect Dis. 2018;67(5):657-666.  

External links on this page are not affiliated with Melinta Therapeutics. Links to sites outside of Melinta are provided as a resource to the viewer. Melinta accepts no responsibility for the content of linked sites. The publications above are intended to share pertinent data regarding Melinta products and associated disease states. The views expressed by the authors are their own, and do not necessarily represent those of Melinta.

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